Microarray Technology and Its Applications [electronic resource] / edited by Uwe R. Mȭller, Dan V. Nicolau.

General Microarray Technologies -- Array Formats -- Biomolecules and Cells on Surfaces Fundamental Concepts -- Surfaces and Substrates -- Reagent Jetting Based Deposition Technologies for Array Construction -- Manufacturing of 2-D Arrays by Pin-printing Technologies -- Nanoarrays -- The Use of Microfluidic Techniques in Microarray Applications -- Labels and Detection Methods -- Marker-free Detection on Microarrays -- DNA Microarrays -- Analysis of DNA Sequence Variation in the Microarray Format -- High Sensitivity Expression Profiling -- Applications of Matrix-CGH (Array-CGH) for Genomic Research and Clinical Diagnostics -- Analysis of Gene Regulatory Circuits -- Protein Microarrays -- Protein, Antibody and Small Molecule Microarrays -- Photoaptamer Arrays for Proteomics Applications -- Biological Membrane Microarrays -- Cell & Tissue Microarrays -- Use of Reporter Systems for Reverse Transfection Cell Arrays -- Whole Cell Microarrays -- Tissue Microarrays for Miniaturized High-Throughput Molecular Profiling of Tumors -- Application of Microarray Technologies for Translational Genomics.

The genomics revolution would not have been possible without the 'parallelisation' offered by microarray technology. This technological - and commercial - success has been since emulated by other applications areas, with a tremendous amplification of innovation. This book describes the fundamentals and latest developments in microarray technology, as well as its future directions. It presents detailed overviews of the different techniques of fabricating microarrays, of the chemistries and preparative steps involved, of the different types of microarrays, and of the instrumentation and optical issues involved.

ZDB-2-SBL