Phosphoinositide 3-kinase in Health and Disease [electronic resource] : Volume 2 / edited by Christian Rommel, Bart Vanhaesebroeck, Peter K. Vogt.
Tipo de material: TextoSeries Current Topics in Microbiology and Immunology ; 347 | Current Topics in Microbiology and Immunology ; 347Editor: Berlin, Heidelberg : Springer Berlin Heidelberg : Imprint: Springer, 2011Descripción: X, 306 p. online resourceTipo de contenido:- text
- computer
- online resource
- 9783642148163
- SpringerLink (Online service)
- 614.5999 23
- RC261-271
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From humble beginnings over 25 years ago as a lipid kinase activity associated with certain oncoproteins, PI3K (phosphoinositide 3-kinase) has been catapulted to the forefront of drug development in cancer, immunity and thrombosis, with the first clinical trials of PI3K pathway inhibitors now in progress. Here the authors give a brief overview of some key discoveries in the PI3K area and their impact, and include thoughts on the current state of the field, and where it could go from here
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