Novel Synthetic Chemistry of Ureas and Amides [electronic resource] / by Marc Hutchby.
Tipo de material: TextoSeries Springer Theses, Recognizing Outstanding Ph.D. Research | Springer Theses, Recognizing Outstanding Ph.D. ResearchEditor: Berlin, Heidelberg : Springer Berlin Heidelberg : Imprint: Springer, 2013Descripción: XVIII, 166 p. online resourceTipo de contenido:- text
- computer
- online resource
- 9783642320514
- SpringerLink (Online service)
- 547 23
- QD415-436
Transition metal catalysis -- Palladium catalysis -- Pd(II) catalysed aminocarbonylation of alkenes -- Carbonylation of aryl ureas -- Urea Hydrolysis -- Amide hydrolysis.
In this thesis, the author investigates the chemistry and application of molecules containing urea and amide bonds. These bonds are some of the strongest known and are fundamental to biological processes. The author describes his discovery that sterically hindered ureas undergo solvolysis at room temperature under neutral conditions. This is a remarkable finding, since ureas are inert under these conditions and a general rule of chemistry is that hindered substrates are less reactive. Remarkably, the author translates these results to the correspondingly sterically hindered amides. This thesis has resulted in a number of outstanding publications in high profile journals. The unique method for breaking urea and amide bonds developed in this study is likely to have far reaching consequences for biological protein manipulation.
ZDB-2-CMS
No hay comentarios en este titulo.